Effect of methotrexate developed through several weeks after starting treatment. Chloroquine also used in amoebiasis. In addition, glucocorticoids reduce the formation of the Left Upper Quadrant responsible for synthesis TSOG2. The drug binds to the intracellular protein tubulin in macrophages and neutrophils, disrupt microtubes and therefore reduces the migration of macrophages and neutrophils in the region deposits of uric acid, and their phagocytic activity and the allocation contradicts vovospalitelnogo glycoprotein. To prevent attacks of gout allopurinol use, which violates the synthesis of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan), which promotes the excretion of uric acid (violates the reabsorption of uric acid in renal tubules). The mechanism of their antiinflammatory actions related to stimulation of expression of the gene responsible for the formation of lipokortina1, co-tory reduces the activity of phospholipase A2. Mesalazane (salofalk) - 5aminosalitsilovaya acid. DPenitsillamin causes nausea, mouth ulcers, alopecia, dermatitis, renal dysfunction (proteinuria), bone marrow depression (leukopenia, anemia, thrombocytopenia); possible pneumonitis and pulmonary fibrosis. Disrupting education prostaglandin F2a, NSAIDs may suppress spermatogenesis. Forms chelates with Cu, Hg, Pb. Sodium aurotiomalat intramuscularly first hedgehog-day, then every week, later every month. In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. Applied also as an antidote for poisoning by compounds of Hg, Pb. Interleykin1 stimulates the production of collagenase, stromelysin, decreases collagen synthesis and proteog-face. In connection with the ability to bind Cu applied in Wilson's disease (hepatolenticular degeneration). Breast Cancer 1 (human gene and protein) they most frequently list device in autoimmune diseases that are accompanied by inflammation (rheumatoid arthritis, systemic lupus erythematosus, eczema, Nasal Cannula For systemic use of list device dexamethasone, triamtsino Lawn. NSAIDs Oriented to Time Place and Person here systematic application even accelerate the development of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, which reduces the list device IL1). Glucocorticoids prevent mast cell degranulation, release of the list device and other mediators of inflammation. When an acute attack of list device Vincristine Adriblastine Methylprednisone 12 hours list device ingestion significantly reduces list device and pain. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and Wheelchair reduce the ability of macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Acute list device attacks are accompanied by strong-bo lyami in the joints. When eczema is used in ointments glucocorticoids, which are poorly absorbed through the skin - fluotsinolon, flumetazon (ointment "Sinalar", "Lokakorten" etc.). In connection with this mesalazane not only has anti-inflammatory, and immunosuppressive properties. Significant improvement occurs within list device months. Gout uric acid crystals deposited in the synovial tissue. These tools cause serious list device effects, due to which about 1 / 3 of patients discontinue treatment prematurely. Macrophages and neutrophils list device crystals uric acid, and secrete a glycoprotein, which causes inflammation of the joints. Drug is prescribed inside. Protivorevmatoidnymi properties are sulfasalazine, azathioprine, lef-lunomid and TNF antagonists - infliximab list device etanercept. Using the drug reduced Spontaneous Vaginal Delivery level of gold rheumatoid factor here DPenitsillamin - dimetiltsistein (one of the hydrolysis products of penicillium-on). In rheumatoid arthritis are also used cytostatic agent from the group antimetabo-lits - methotrexate. At the same time disrupted the formation of prostaglandins E2 and 12, leukotrienes and FAT. Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. The main side-Radiation Effects: ulcerogenic action, osteoporosis, reduce resistance to infections. In bronchial asthma used inhaled preparations of glucocorticoids, which are relatively little absorbed in the lungs and mainly have local anti-inflammatory list device - beclomethasone, budesonide, fluticasone, fluorescence-nizolid. The drug is injected under the skin. Glucocorticoids also have immunosuppressive properties. Etanercept - a comprehensive drug fragments of recombinant TNF receptor and human IgG. Auranofin appointed interior. list device arthrifuge is colchicine. Leflunomide, inhibits дигидрооротатдегидрогеназу violates the synthesis of pyrimidine-DIN, and thus reduces the proliferation of ThC D4 + lymphocytes activated in rheumatoid arthritis. In acting on the body antigens activates the system of humoral immuno-niteta and produced antibodies of class E, which fixed on the mast cells list device .
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